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confidence high
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materiality 0.60
Telomir-1 kills aggressive human leukemia cells in vitro; expands oncology profile into blood cancers
Telomir Pharmaceuticals, Inc.
- Telomir-1 produced dose-dependent reduction in viability of human HL60 leukemia cells (aggressive AML model).
- Leukemia cells depend on intracellular iron; Telomir-1 lowers intracellular Fe²⁺ more potently than DFO.
- Prior research shows Telomir-1 reduces abnormal DNA methylation of tumor-suppressor genes and inhibits KDM histone demethylases.
- Findings add to previously reported activity against triple-negative breast, pancreatic, and prostate cancer models.
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