other material
confidence high
sentiment positive
materiality 0.65
MIRA's SKNY-1 shows favorable oral bioavailability, brain penetration in preclinical studies
MIRA PHARMACEUTICALS, INC.
- Optimized oral formulation of SKNY-1 demonstrated favorable oral bioavailability and reproducible systemic exposure in preclinical PK study.
- Robust brain penetration and substantial liver exposure observed; peak plasma concentrations at 6-12 hours support once-daily oral dosing.
- Findings complement prior efficacy studies showing weight reduction, lean mass preservation, and reduced compulsive feeding/nicotine-seeking.
- SKNY-1 designed with biased CB1 modulation, CB2 agonism, and selective MAO-B inhibition; no anxiety-like behavior in preclinical model.