8-K
filed June 1, 2026, 6:57 AM ET
ticker SMMT
CIK 0001599298
other material
confidence high
sentiment positive
materiality 0.85
Ivonescimab: 70.8% ORR in mCRC Phase II; HARMONi-6 OS HR 0.66 vs tislelizumab
Summit Therapeutics Inc.
- Phase II AK112-206 in 1L mCRC: ORR 70.8%, DCR 100.0% in evaluable patients (n=48); 9-month PFS rate 76.1% for 20 mg/kg arm.
- HARMONi-6 Phase III in squamous NSCLC: OS HR 0.66 (p=0.0017) vs tislelizumab + chemo; 24-month OS rates 64.7% vs 48.6%.
- Ivonescimab + chemo reduced risk of death by 34% vs tislelizumab; first Phase III to show significant OS benefit over anti-PD-1 + chemo in 1L NSCLC.
- Safety profiles manageable; no new safety signals; TRAEs leading to discontinuation in HARMONi-6: 5.3% vs 4.5%.
- Data presented at ASCO 2026; HARMONi-6 results simultaneously published in The Lancet; Summit to host conference call June 1.
Machine-readable event card
- schema_version
- secwatch.filing_event.v1
- accession
- 0001599298-26-000043
- form_type
- 8-K
- ticker
- SMMT
- cik
- 0001599298
- company_name
- Summit Therapeutics Inc.
- filed_at
- 2026-06-01T10:57:20+00:00
- discovered_at
- 2026-06-01T11:00:00.239558+00:00
- generated_at
- 2026-06-01T11:00:34.911587+00:00
- sec_items
- ["8.01", "9.01"]
- event_type
- other_material
- sentiment
- positive
- materiality_score
- 0.85
- calibrated_materiality_score
- 0.85
- confidence
- high
- secwatch_canonical_url
- https://secwatch.observer/filing/0001599298-26-000043
- json_url
- https://secwatch.observer/filing/0001599298-26-000043.json
- markdown_url
- https://secwatch.observer/filing/0001599298-26-000043.md
- text_url
- https://secwatch.observer/filing/0001599298-26-000043.txt
- edgar_index_url
- https://www.sec.gov/Archives/edgar/data/1599298/000159929826000043/0001599298-26-000043-index.htm
- edgar_primary_document_url
- https://www.sec.gov/Archives/edgar/data/1599298/000159929826000043/smmt-20260530.htm
- generated_by_model
- deepseek-v4-flash:cloud@v2
- review_status
- machine_generated
- human_reviewed
- false
- corrected
- false
- correction_note
- null
- correction_timestamp
- null
- superseded_by
- null
Comparable filings
CSR
Centerspace approves $240-245M asset sales; exits Bismarck and Rapid City
CENTERSPACE
June 1, 2026, 4:30 PM ET
other_material
Items 7.01, 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
DGAC
Disciplined Growth Acquisition Corp. closes $150M IPO on NYSE
DISCIPLINED GROWTH ACQUISITION Corp
June 1, 2026, 4:15 PM ET
other_material
Items 1.01, 3.02, 5.02, 5.03, 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
IDYA
IDEAYA's darovasertib combo meets primary endpoint in Phase 2/3 OptimUM-02 trial for metastatic uveal melanoma
IDEAYA Biosciences, Inc.
June 1, 2026, 4:05 PM ET
other_material
Items 7.01, 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
FULC
Fulcrum Therapeutics discontinues pociredir program in SCD; initiates strategic review
Fulcrum Therapeutics, Inc.
June 1, 2026, 4:05 PM ET
other_material
Items 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
GPRO
GoPro refiles financials with going-concern warning; potential defaults on debt
GoPro, Inc.
June 1, 2026, 9:12 AM ET
other_material
Items 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
OPTU
Optimum raises $500M via preferred units, starts $300M tender at $2.50 to shield assets from CSC debt
Optimum Communications, Inc.
June 1, 2026, 8:16 AM ET
other_material
Items 1.01, 3.02, 7.01, 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
STSS
Sharps Technology rebrands as SkyAI, pivots to AI finance platform for Global South
Sharps Technology Inc.
June 1, 2026, 8:15 AM ET
other_material
Items 5.03, 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
NXTC
NextCure Phase 1 SIM0505 data: 55% ORR in gynecologic cancers; cash into Q1 2027
NextCure, Inc.
June 1, 2026, 8:10 AM ET
other_material
Items 7.01, 8.01, 9.01
same SEC item: 8.01, 9.01
same event type: other_material
similar materiality
Filing page
SEC filing
This headline and bullets were generated automatically by deepseek-v4-flash:cloud@v2 from the public filing. Read the source on SEC.gov before relying on any specific claim. Not investment advice.
See methodology for how this pipeline works.