Highest-materiality recent filing
All nine director nominees elected with strong support; highest withheld votes were 25M for Kenneth A. Clark.
Summit Therapeutics withdraws proposed public offering due to market conditions
Effective June 10, 2026, Summit Therapeutics withdrew its previously announced proposed underwritten public offering of securities.
Summit Therapeutics authorizes affiliates and executives to purchase shares under ATM offering
Audit Committee and independent directors approved company affiliates to buy shares under existing ATM with JP Morgan.
Ivonescimab: 70.8% ORR in mCRC Phase II; HARMONi-6 OS HR 0.66 vs tislelizumab
Phase II AK112-206 in 1L mCRC: ORR 70.8%, DCR 100.0% in evaluable patients (n=48); 9-month PFS rate 76.1% for 20 mg/kg arm.
Summit Q1 net loss $189.4M, cash $598.7M; ivonescimab OS data at ASCO plenary
GAAP net loss $189.4M ($0.24/sh) vs $62.9M ($0.09/sh) YoY; non-GAAP net loss $116.6M ($0.15/sh).
Summit FY25 GAAP net loss $1.08B, BLA accepted with PDUFA Nov 14, HARMONi-3 interim PFS Q2 2026
GAAP net loss $1,079.6M ($1.44/sh) vs $221.3M ($0.31/sh) FY24; non-GAAP net loss $347.2M ($0.46/sh).
Summit Therapeutics BLA for ivonescimab in EGFR-mutated NSCLC accepted by FDA; PDUFA Nov 14, 2026
FDA accepted BLA for ivonescimab + chemotherapy in EGFR-mutated non-squamous NSCLC post-TKI therapy.
Summit submits BLA for ivonescimab in EGFRm NSCLC; $710M cash; GSK collaboration
BLA submitted to FDA for ivonescimab + chemo in 2L+ EGFR-mutated NSCLC based on Phase III HARMONi; FDA decision expected Q4 2026.
Ivonescimab + chemo shows OS benefit in EGFRm NSCLC; HR 0.74 in HARMONi-A final analysis
Final OS analysis: ivonescimab+chemo vs chemo achieved HR 0.74 (95% CI: 0.58-0.95, p=0.019); median OS 16.8 vs 14.1 months.
Summit Therapeutics raises $500M in private placement at $18.74/share; insiders invest $282M
Raised $500M gross and net proceeds from sale of 26.68M shares at $18.74 each, the closing price on Oct 21, 2025.
Summit plans BLA for ivonescimab in Q4 2025; HARMONi-6 meets endpoint
Plans to submit BLA for ivonescimab plus chemotherapy in EGFRm NSCLC in Q4 2025 based on HARMONi study.
Ivonescimab HARMONi trial shows improved OS trend in longer follow-up; North American HR=0.70
Longer-term follow-up of Western patients: OS HR=0.78 (nominal p=0.0332); median OS 16.8 vs 14.0 months.
Summit Therapeutics expands ATM offering capacity by $360M to total $450M
Increased ATM equity offering capacity by $360M; total authorized up to $450M under agreement with J.P. Morgan.
Ivonescimab HARMONi PFS HR 0.52, NMPA approval; Summit Q2 net loss $565.7M
HARMONi PFS HR 0.52 (p<0.00001); OS trend HR 0.79 (p=0.057); BLA filing planned.
Summit Therapeutics sub-subleases 36,406 sq ft Palo Alto office; ~$2.8M annual rent
Sub-sublease for 36,406 sq ft in Palo Alto, CA, effective June 16, 2025, starting Jan 1, 2026, expiring Oct 28, 2033.
Summit Therapeutics stockholders approve all proposals at 2025 annual meeting
All nine director nominees elected (Duggan, Zanganeh, Soni, Clark, Booth, Cesano, Xia, Ronaghi, Huber) with >98% support.
Summit's ivonescimab meets PFS endpoint in global Phase III HARMONi; OS trend positive
Ivonescimab + chemo reduced risk of progression or death by 48% vs chemo alone (HR 0.52; p<0.00001).
Summit Therapeutics Q1 net loss widens to $62.9M; ivonescimab gets second China approval
GAAP net loss $62.9M ($0.09/share) vs $43.5M ($0.06) in Q1 2024; R&D expenses rose to $51.2M.
Summit: Ivonescimab gets second NMPA approval in China; OS hazard ratio 0.777
NMPA approved ivonescimab for front-line PD-L1+ advanced NSCLC based on HARMONi-2 Phase III trial.
Ivonescimab + chemo beats tislelizumab + chemo in Phase III squamous NSCLC trial (HARMONi-6)
Primary endpoint PFS met: statistically significant and clinically meaningful improvement by BICR versus tislelizumab combo.
Summit Therapeutics reports FY2024 net loss $221.3M; HARMONi enrollment complete, data mid-2025
Cash & short-term investments $412.3M at Dec 31, 2024, up from $186.2M at Dec 31, 2023.
Summit Therapeutics discloses ~$412M cash balance, awards $540K bonuses to CEO/CFO
Preliminary unaudited cash, equivalents, and short-term investments ~$412M as of Dec 31, 2024, including $31.8M loan repayment.
Summit Therapeutics reports preliminary cash ≥$410M as of Dec 31, 2024
Preliminary unaudited cash, cash equivalents, and short-term investments at least $410M.
Summit reports Q3 net loss $56.3M; ivonescimab HARMONi-2 shows 49% risk reduction vs Keytruda
Cash and short-term investments $487M (vs $186.2M Dec 2023) after $235M private financing in Sep 2024.
Summit Therapeutics raises $235M in private placement led by insiders at $22.70/share
Sold 10.35M shares at $22.70, the closing price on Sept 11; aggregate gross proceeds ~$235M.
Summit reports ivonescimab beats Keytruda in Phase 3 NSCLC trial; PFS HR=0.51 p<0.0001
Ivonescimab vs pembrolizumab in 1L PD-L1+ advanced NSCLC: mPFS 11.14 vs 5.82 months (HR 0.51, p<0.0001).
Summit Therapeutics Q2 net loss $60.4M; ivonescimab achieves first Phase III win over Keytruda
GAAP net loss $60.4M ($0.09/sh) vs $14.7M ($0.02) in Q2 2023; non-GAAP loss $34.3M.
Summit Therapeutics appoints Jeff Huber, ex-Google SVP and GRAIL co-founder, to board
Jeff Huber elected to Summit board effective June 27, 2024; will serve on Audit Committee.
Summit Therapeutics director Ujwala Mahatme resigns; annual meeting elects all eight nominees
Director Ujwala Mahatme resigned effective June 12, 2024, to focus on professional commitments; no disagreement with company.
Ivonescimab plus chemo gets NMPA approval in China for EGFRm NSCLC; PFS HR 0.46 in HARMONi-A
NMPA approved ivonescimab + chemo for 2L+ EGFR-mutant non-squamous NSCLC based on HARMONi-A Phase III trial sponsored by Akeso.
Summit raises $200M, expands ivonescimab license to LAMEA regions
Raised $200M via private placement of 22.2M shares at $9.00/share, a premium to the prior close.
Summit: Ivonescimab beats pembrolizumab in Phase III HARMONi-2 for PD-L1+ NSCLC
Ivonescimab met primary endpoint PFS with statistically significant and clinically meaningful superiority over pembrolizumab.
Summit partner Akeso wins China NMPA approval for ivonescimab in EGFR-mutated NSCLC
NMPA approved ivonescimab + chemo for EGFR-mutated advanced non-squamous NSCLC after TKI failure.
Summit Therapeutics enters $90M ATM equity distribution agreement with JPMorgan
Up to $90M of common stock may be sold at-the-market through J.P. Morgan Securities LLC as sales agent.
GAAP net loss $43.5M ($0.06/sh) vs $542.3M ($1.43/sh) prior year; non-GAAP net loss $34.0M ($0.05/sh).
Summit Therapeutics appoints Dr. Mostafa Ronaghi to board of directors
Dr. Ronaghi elected to board and Compensation Committee effective April 11, 2024.
Summit Therapeutics CFO resigns; COO Manmeet Soni appointed new CFO
CFO Ankur Dhingra resigned April 2, 2024, not due to any disagreement with the company.
Ivonescimab shows 34% intracranial response in NSCLC brain mets; median PFS 19.3 months
Intracranial response rate 34% (23% complete) in NSCLC patients with brain metastases; median PFS 19.3 months.
Summit Therapeutics presents at Barclays conference; no new material disclosed in filing excerpt
Presentation slides made available on March 12, 2024 at Barclays Global Healthcare Conference.
Summit Therapeutics to present at Barclays Healthcare Conference on March 12
Will present on Tuesday March 12, 2024 at 2:35pm ET.
GAAP net loss Q4 2023 $36.6M ($0.05/sh) vs $19.3M ($0.07/sh) a year ago; full-year loss $614.9M primarily from $500M ivonescimab licensing fee.
Summit Therapeutics presents at Oppenheimer conference; no material new information in filing
Presented at Oppenheimer's 34th Annual Healthcare Life Sciences Conference on February 14, 2024.
Summit Therapeutics to present at Oppenheimer Healthcare Conference on Feb 14
Presentation at Oppenheimer's 34th Annual Healthcare Life Sciences Conference on February 14, 2024 at 2:40PM ET.
Ivonescimab Phase II shows 64.8% 24-month OS in 1L squamous NSCLC; cash ≥$186M
Phase II AK112-201: 24-month OS rate 64.8% in 63 1L squamous NSCLC patients; median OS not reached after 21.0 months follow-up.
Summit Therapeutics to present at J.P. Morgan Healthcare Conference on Jan 9, 2024
Presentation on January 9, 2024 at 1:30 PM PT; includes update on ivonescimab development.
Summit Therapeutics Q3 net loss $21.3M; starts second Phase III for ivonescimab
Net loss Q3 $21.3M; nine-month 2023 net loss $578.4M includes $520.9M one-time IPR&D charge from ivonescimab licensing.
Ivonescimab shows 18-fold increased PD-1 binding affinity in presence of VEGF at SITC
Poster at SITC 2023 details cooperative binding: 18x higher PD-1 affinity with VEGF present in vitro.
Summit appoints Manmeet Soni as COO; Soni invests $5M, receives 28M options
Soni named COO effective Oct 13, 2023; invested $5M for 2.98M shares at $1.68/share.
Summit Therapeutics Q2 net loss $14.7M; cash at $215M; HARMONi trials underway
Net loss for Q2 2023 was $14.7M vs $16.8M YoY; six-month net loss $557.1M including $520.9M one-time IPR&D charge for ivonescimab license.
Summit Therapeutics schedules Q2 2023 earnings call for August 9
Press release announces Q2 2023 financial results and operational update call on August 9, 2023 before market open.
Effective June 12, 2024, Ujwala Mahatme informed Summit Therapeutics Inc. (the “Company”) that she was resigning from her role as a member of the Board of Directors (the “Board”) of the Company, and from each committee of the Board, to focus on her increasing professional commitments outside the Company.
the board of directors (the “Board”) of Summit Therapeutics Inc. (the “Company”) unanimously approved the election of Mostafa Ronaghi, PhD, as a director of the Company and the appointment of Dr. Ronaghi to serve on the Compensation Committee of the Board.
On April 2, 2024, the Company hired Bhaskar Anand as Chief Accounting Officer, Head of Finance, to serve as its principal accounting officer.
On April 2, 2024, Ankur Dhingra, the principal financial officer and principal accounting officer of Summit Therapeutics Inc. (the “Company”), resigned as Chief Financial Officer of the Company.
the Company appointed its Chief Operating Officer Manmeet Soni to the office of Chief Financial Officer, in which capacity he will serve as the Company’s principal financial officer, in addition to his continuing service as Chief Operating Officer.
On October 13, 2023, the Company appointed Manmeet S. Soni as its Chief Operating Officer.
the Board of Directors (the “Board”) of the Company appointed Dr. Yu (Michelle) Xia to serve as a member of the Board pursuant to the terms of the License Agreement.
the Board unanimously approved the election of Dr. Yu (Michelle) Xia as a director of the Company, effective upon the Antitrust Clearance Date.
Effective on November 15, 2022, the board of directors (the “Board”) of Summit Therapeutics Inc. (the “Company”) unanimously approved (i) the election of Dr. Alessandra Cesano, MD, PhD as a director of the Company and (ii) the appointment of Dr. Cesano to serve on the Compensation Committee and the Nominating and Corporate Governance Committee of the Board.
effective September 28, 2022, Urte Gayko resigned from the Board of the Company in order to create a vacancy for Dr. Robert Booth, PhD
On September 28, 2022, the Board unanimously approved (i) the election of Dr. Robert Booth, PhD as a director
Effective July 25, 2022, the board of directors (the “Board”) of Summit Therapeutics Inc. (the “Company”) appointed Dr. Maky Zanganeh to serve as Co-Chief Executive Officer and President of the Company.
Max materiality 0.90 · Median 0.68 · Most common event other_material