Krystal Biotech stockholders elect three Class III directors at 2023 annual meeting

Proposal Three: Non-Binding, Advisory Vote On Named Executive Officer Compensation The Company’s stockholders approved, on an advisory (non-binding) basis, the compensation of the Company’s named executive officers for the fiscal year ended December 31, 2022, as disclosed in the Company’s proxy statement for the Annual Meeting pursuant to the compensation disclosure rules of the Securities and Exchange Commission. The results of the vote were as follows: Votes For Votes Against Abstentions Broker Non-Votes 18,759,786 907,235 7,389 2,431,170

Proposal One: Election of Class III Directors The Company’s stockholders elected Krish S. Krishnan, Kirti Ganorkar, and Christopher Mason as members of the Company’s Board of Directors as Class III directors for a three-year term. The results of the vote were as follows: Nominee Votes For Votes Withheld Broker Non-Votes Krish S. Krishnan 15,620,498 4,053,912 2,431,170 Kirti Ganorkar 14,761,072 4,913,338 2,431,170 Christopher Mason 15,864,807 3,809,603 2,431,170

Proposal Two: Ratification of Appointment of Independent Registered Public Accounting Firm The Company’s stockholders ratified the appointment of KPMG LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2023. The results of the vote were as follows: Votes For Votes Against Abstentions 22,098,460 2,547 4,573