other material
confidence high
sentiment positive
materiality 0.75
Scholar Rock reports 36-month TOPAZ data: sustained motor function and safety; Phase 3 on track
Scholar Rock Holding Corp
- Mean HFMSE change from baseline at 36 months: +4.0 points (95% CI 1.0-6.9, N=28).
- Mean RULM change from baseline at 36 months: +2.4 points (95% CI 1.1-3.7, N=27).
- PEDI-CAT daily activity +2.2; PROMIS-Fatigue -4.6 at 36 months, consistent with motor gains.
- Safety: 198 patient-years exposure; >90% remained on study; no new safety signals or ADA.
- Phase 3 SAPPHIRE enrollment expected to complete Q3 2023.