BMF-650 preclinical shows 12-15% weight loss in obese monkeys; IND on track H2 2025

Biomea Fusion, Inc.

28-day study in 15 obese cynomolgus monkeys; oral BMF-650 at 10 or 30 mg/kg daily.
Weight loss of 12% (10 mg/kg) and 15% (30 mg/kg) from baseline at Day 28.
Daily food intake reduced to 35g (10 mg/kg) and 16g (30 mg/kg) vs 109g for vehicle.
IND submission for BMF-650 on track for second half of 2025.
Full preclinical data set planned for upcoming medical conference presentation.

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