Tivic Health study: personalized ncVNS boosts HRV 46%, 8.9x vs fixed frequency

Valion Bio, Inc.

Personalizing stimulation frequency increased heart rate variability by 46%, 8.9x more effective than uniform frequency across subjects.
Optimal frequency varied between visits for each subject, highlighting need for pre-treatment personalization.
Electrode placement significantly impacted HRV; some configurations reduced HRV markedly while others increased it.
Four minutes of ncVNS stimulation drove large HRV increase and was more effective than twenty minutes.
CEO sees potential clinical utility in ischemic stroke, PTSD, and inflammatory diseases; plans in-house or partnered development.

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