Recent 8-K filings for SION

• May 12, 2026, 7:08 AM ET earnings materiality 0.60 positive item 2.02item 9.01 ◈ Earnings Releases

  Sionna Therapeutics Q1 net loss $26.8M; Phase 2a enrollment completed for SION-719

  Net loss of $26.8M for Q1 2026, compared to $16.5M in Q1 2025.

• November 5, 2025, 6:59 PM ET earnings materiality 0.70 positive item 2.02item 9.01

  Sionna Q3 net loss $20.3M; starts Phase 2a trial for SION-719; cash runway into 2028

  Net loss of $20.3M in Q3 2025 versus $25.4M in Q3 2024; R&D expenses fell to $16.0M from $24.6M due to prior year license charge.

• August 11, 2025, 7:59 PM ET earnings materiality 0.60 positive item 2.02item 9.01

  Sionna Therapeutics Q2 net loss $18.1M; positive Phase 1 data for NBD1 stabilizers

  Net loss $18.1M in Q2 2025 vs $8.6M in Q2 2024; R&D expenses $15.4M.

• June 4, 2025, 7:59 PM ET other material materiality 0.70 positive item 7.01item 9.01

  Sionna reports positive Phase 1 data for NBD1 stabilizers SION-719 and SION-451; advances both to next trials

  Both SION-719 and SION-451 were generally well tolerated with no serious adverse events or discontinuations.

• May 12, 2025, 7:59 PM ET earnings materiality 0.65 neutral item 2.02item 9.01

  Sionna Therapeutics Q1 net loss $16.5M; cash $354.7M; Phase 1 dosing complete for two NBD1 stabilizers

  Net loss of $16.5M for Q1 2025, up from $11.8M in Q1 2024; R&D expenses $13.7M vs $10.2M.

• March 20, 2025, 7:59 PM ET earnings materiality 0.75 negative item 2.02item 9.01

  Sionna Therapeutics FY2024 net loss $61.7M; cash $168M plus $199.6M IPO net proceeds extend runway into 2028

  Net loss Q4 2024 $15.8M, full year $61.7M vs $47.3M in 2023; R&D spend $57.3M.

Earnings & guidance

Materiality & sentiment trend

Max materiality 0.75 · Median 0.60 · Most common event earnings

4 positive 1 negative 5 neutral

source · SION on sec.gov