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Entrada reports positive Phase 1/2 data for ENTR-601-44 in DMD; Q1 net loss $39.7M
Cohort 1 of ELEVATE-44-201 met primary safety endpoint: no SAEs, no discontinuations, kidney markers normal.
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Entrada posts Q4 net loss of $39.2M; cash at $295.7M; DMD program advances
Net loss of $39.2M in Q4 2025 vs net income of $1.1M in Q4 2024; full-year net loss of $143.8M.
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Entrada reports ~$296M cash, completes DMD cohort 1, expands pipeline into ocular disease with ENTR-801
Preliminary cash, cash equivalents and marketable securities of ~$296M as of Dec 31, 2025; cash runway into Q3 2027.
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Entrada Q3 net loss widens to $44.1M; DMD pipeline on track for data in 2026
Net loss of $44.1M for Q3 2025, compared to $14.0M net loss in Q3 2024; collaboration revenue fell to $1.6M from $19.6M.
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Entrada Therapeutics reports Q2 net loss of $43.1M; cash runway into Q2 2027; advances DMD trials
Net loss of $43.1M in Q2 2025 vs net income of $55.0M in Q2 2024; collaboration revenue fell from $94.7M to $2.0M.
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Entrada reports Q1 net loss of $17.3M, gets EU clearance for DMD exon 44 trial, cuts workforce 20%
Net loss of $17.3M in Q1 2025 vs net income $23.5M Q1 2024; collaboration revenue fell to $20.6M from $59.1M.
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Entrada Therapeutics restructures, reduces workforce 20% to focus on Duchenne MD candidates
Board approved strategic plan on April 29, 2025; workforce reduction of approximately 20% effective May 2.
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Entrada Q4 net income $1.1M; FDA lifts hold on ENTR-601-44; cash $420M into Q2 2027
Q4 net income $1.1M vs loss $9.5M YoY; FY net income $65.6M vs loss $6.7M.
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FDA lifts clinical hold on Entrada's ENTR-601-44 for DMD Phase 1b study
FDA authorized ELEVATE-44-102, a Phase 1b multiple ascending dose study of ENTR-601-44 in adults with DMD amenable to exon 44 skipping.
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Entrada gets UK MHRA nod for Phase 1/2 trial of DMD candidate ENTR-601-44
UK MHRA and REC authorized ELEVATE-44-201, a global Phase 1/2 MAD study of ENTR-601-44 for DMD exon 44 skipping.
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Entrada reports ~$420M cash; DMD pipeline advancing with multiple 2025 trial starts
Preliminary cash resources ~$420M as of Dec 31, 2024, extending runway into Q2 2027.
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Entrada Q2 net income $55M, positive Phase 1 data for DMD candidate ENTR-601-44
Q2 net income of $55.0M vs net loss of $25.9M YoY; collaboration revenue $94.7M (up from $18.2M).
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Entrada reports positive Phase 1 data for ENTR-601-44; plans Phase 2 trials in Q4 2024
No serious or drug-related adverse events; ENTR-601-44 well-tolerated across all 4 dose cohorts (0.75-6 mg/kg) in 32 healthy volunteers.
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Entrada Therapeutics raises $100M in registered direct offering to fund pipeline
Gross proceeds of $100M from sale of 3,367,003 shares at $14.85 and pre-funded warrants at $14.8499.
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Entrada Q1 net income $23.5M; Vertex $75M milestone; DMD Phase 1 final cohort dosed; cash runway to Q2 2026
Net income $23.5M vs loss ($6.7M) Q1 2023; collaboration revenue $59.1M (up from $25.3M) on Vertex $75M milestone.
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Entrada Therapeutics FY2023 net loss $6.7M, cash $352M; DMD Phase 1 data on track
Cash, equivalents and marketable securities $352.0M as of Dec 31, 2023, up from $188.7M; runway through Q2 2026.
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Entrada completes first two cohorts in Phase 1 for ENTR-601-44; US clinical hold remains
Completed dosing of first and second cohorts in Phase 1 trial ENTR-601-44-101 in the UK.
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Entrada Therapeutics Q3 net income $35.5M; initiates Phase 1 for DMD candidate ENTR-601-44
Net income of $35.5M in Q3 2023 vs net loss of $(25.1M) in Q3 2022, driven by $43.7M collaboration revenue.
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Entrada gets $223.7M upfront from Vertex amendment; $17.5M milestone reached for ENTR-701
Received $223.7M upfront payment from Vertex under amended collaboration/license agreements.
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Entrada Therapeutics enters into $150M at-the-market offering agreement with Cowen
Entered into sales agreement with Cowen and Company for at-the-market offering of up to $150M in common stock.
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Entrada Q2 cash $376.8M; on track to dose first participant in ENTR-601-44 Phase 1 in Sept 2023
Cash, cash equivalents and marketable securities of $376.8M as of June 30, 2023, up from $188.7M at year-end 2022; cash runway extended through 2025.
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Entrada Therapeutics gets UK authorization to start Phase 1 trial of ENTR-601-44 for Duchenne
UK MHRA and REC authorized Phase 1 CTIMP for ENTR-601-44 in healthy volunteers for exon 44 skipping Duchenne.
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Entrada Q1 net loss $6.7M, cash $411.6M; advancing Duchenne pipeline despite clinical hold
Cash, cash equivalents and marketable securities $411.6M at March 31, 2023, up from $188.7M at Dec 31, 2022.
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Entrada Therapeutics appoints Dr. Bernhardt Zeiher to Board of Directors
Board expanded from 7 to 8; Dr. Zeiher appointed as Class II director and to Nominating and Corporate Governance Committee.
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Entrada reports FY2022 net loss $94.6M; Vertex deal adds $224M upfront, extends cash into 2H 2025
Net loss $24.6M Q4, $94.6M FY2022; R&D expenses $15.7M Q4, $66.6M FY2022.
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Entrada closes $224M upfront Vertex collaboration for DM1; cash runway to H2 2025
Closed global collaboration with Vertex for ENTR-701 and other DM1 research; Vertex leads development.
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Entrada receives FDA clinical hold on IND for ENTR-601-44 in Duchenne muscular dystrophy
Clinical hold placed on IND for ENTR-601-44, a potential treatment for DMD with exon 44 skippable mutations.
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Entrada licenses DM1 program to Vertex for $224M upfront, $26M equity, up to $485M milestones
Upfront payment of ~$224M plus $26M equity investment; potential milestones up to $485M and tiered mid-to-high single-digit royalties on net sales.
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Entrada Therapeutics reports Q2 2022 net loss of $23.2M; cash runway into 2H 2024
Cash, cash equivalents and marketable securities $244.3M as of June 30, 2022, sufficient into 2H 2024.
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Entrada Q1 net loss $21.7M; announces second candidate ENTR-701 for DM1; IND on track for Q4 2022
Q1 2022 net loss of $21.7M vs $8.4M YoY; R&D expenses rose to $15.7M from $6.2M.
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Entrada Therapeutics signs 10-year lease for ~81,442 sq ft HQ in Boston
Lease for fifth and sixth floors of One Design Center Place, Boston; 10-year term with 5-year renewal option.
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Entrada reports Q3 2021 net loss $14.4M and closes $208.7M IPO
Net loss for Q3 2021 was $14.4M vs $7.0M in Q3 2020; R&D expense $10.5M, G&A $3.9M.