Lara Sullivan
Also on the Effective Date, Dr. Sullivan resigned from the Board of Directors of the Company.
Highest-materiality recent filing
Pyxis Oncology Q2 net loss $25.3M; $50M private placement extends cash runway into Q2 2027
Net loss $25.3M ($0.40/share) vs $18.4M ($0.30) in Q2 2025; R&D $16.1M, G&A $9.9M.
Pyxis Oncology raises $50M upfront in private placement; warrants could add $64M
Gross proceeds of ~$50M from 19.6M shares at $2.551/share; warrants at $3.289 for additional ~$64M if exercised.
Pyxis Oncology shareholders elect three Class II directors, ratify E&Y as auditor
Quorum of 47,302,035 of 62,855,464 shares present at June 15 annual meeting.
Pyxis Oncology Q1 2026 net loss $23.3M; MICVO data on track for mid-2026
Net loss $23.3M ($0.37/share) vs $21.2M ($0.35/share) YoY; R&D expenses rose to $20.0M from $17.0M.
Pyxis Oncology enters CEO separation agreement: 18-mo salary, equity acceleration, board resignation
Separation Agreement with former CEO Lara Sullivan became binding April 29, 2026; she resigned from Board same day.
Pyxis Oncology completes MICVO enrollment, reports FY2025 net loss of $79.6M, names Interim CEO
Completed target enrollment (n~40) for MICVO Phase 1 monotherapy dose expansion in 2L+ R/M HNSCC in Q1 2026.
Pyxis Oncology CEO Dr. Lara Sullivan steps down; board member Tom Civik appointed interim CEO
Effective February 2, 2026, Dr. Lara Sullivan stepped down as President, CEO, and CMO of Pyxis Oncology.
Pyxis Oncology MICVO Phase 1 shows 46% ORR monotherapy, 71% ORR with Keytruda in HNSCC
MICVO monotherapy at 5.4 mg/kg: 46% confirmed ORR (6/13), 92% DCR in 2L+ R/M HNSCC; no Grade 4/5 TRAEs.
Pyxis Oncology Q3 net loss $22.0M; cash $77.7M, runway into H2 2026
Net loss $22.0M ($0.35/share) for Q3 2025, vs $21.2M loss in Q3 2024.
Pyxis Oncology Q2 2025 net loss $18.4M, cash $90.4M; MICVO data milestones ahead
Revenue of $2.8M from milestone payment for suvemcitug approval in China, compared to $0 in Q2 2024.
Revised ClinicalTrials.gov entry for MICVO (PYX-201) Phase 1 monotherapy trial reflects maximum patient enrollment per protocol.
Pyxis Oncology CFO/COO Pamela Connealy retires; Jitendra Wadhane appointed PFO
Pamela Connealy, CFO and COO, retired from Pyxis Oncology effective July 1, 2025; not due to any disagreement.
Pyxis Oncology annual meeting elects three directors, ratifies EY auditor
Elected Dr. Santhosh Palani, Darren Cline, and Dr. Rachel Humphrey as Class I directors until 2028.
Pyxis Oncology Q1 net loss $21.2M ($0.35); cash $106.9M; MICVO data on track for H2 2025
Net loss $21.2M ($0.35/share) vs $3.3M ($0.06) in Q1 2024; prior year included $16.1M Novartis settlement revenue.
Pyxis Oncology posts updated investor presentation; no specific new data disclosed
Updated corporate presentation dated March 24, 2025, posted on company IR website.
Pyxis Oncology reports FY2024 net loss $77.3M; MICVO 50% ORR in HNSCC; workforce cut 20%
Full year 2024 net loss $77.3M ($1.32 per share) vs $73.8M ($1.85) in 2023; cash $128.4M into 2H26.
Pyxis Oncology receives FDA Fast Track for PYX-201 in head and neck cancer
FDA granted Fast Track Designation to PYX-201 for recurrent/metastatic HNSCC after prior chemo and anti-PD-(L)1.
Pyxis Oncology initiates combo trial PYX-201 + Keytruda and monotherapy expansion in HNSCC
Phase 1/2 combo trial PYX-201-102 with Keytruda (pembrolizumab) in multiple solid tumors including R/M HNSCC, HR+/HER2- BC, TNBC; first dosing on track for Q1 2025.
Pyxis Oncology prioritizes PYX-201 after 50% ORR in HNSCC; suspends PYX-106
Confirmed 50% ORR and 100% DCR in 6 heavily pretreated HNSCC patients in Phase 1 of PYX-201.
PYX-201 achieves 50% ORR in HNSCC; Merck collaboration for KEYTRUDA combo
PYX-201 achieved 50% confirmed ORR by RECIST 1.1 (1 CR, 2 PR) and 100% DCR in 6 heavily pretreated HNSCC patients.
Pyxis Oncology reports Q3 2024 net loss of $21.2M; cash runway into 2H 2026
Cash and equivalents of $146.3M as of Sept 30, 2024; expected to fund operations into 2H 2026.
Pyxis Oncology shareholders approve 5.5M share increase in equity plan at special meeting
Shareholders voted 23,234,250 to 12,829,636 to approve amendment to 2021 Equity and Incentive Plan adding 5,500,000 shares.
Pyxis Oncology Q2 net loss $17.3M; cash $157.2M funds into 2H 2026
Net loss $17.3M ($0.29/shr) vs $15.9M ($0.41/shr) in Q2 2023; R&D spend $13.9M.
Pyxis Oncology stockholders elect four directors, ratify Ernst & Young as auditor
Dr. Santhosh Palani elected Class I director with 28,241,400 for, 93,674 withheld.
Pyxis Oncology appoints Michael A. Metzger (CEO of Syndax) to board effective June 10, 2024
Michael A. Metzger appointed to Pyxis Oncology Board as Class II director, effective June 10, 2024.
Pyxis Oncology Q1 net loss narrows to $3.3M; PYX-201 data on track for fall 2024
Revenue of $16.1M from Novartis royalty settlement; net loss $3.3M ($0.06/sh) vs $19.2M ($0.54/sh) YoY.
Pyxis Oncology sells royalty rights to Novartis for $8M upfront cash
One-time $8M payment from Novartis for rights to Beovu and another asset royalties.
Pyxis Oncology files pro forma financials for Apexigen acquisition; combined net loss $97.8M
Pro forma combined net loss for FY 2023: $97.8M (basic EPS $2.29).
Pyxis Oncology reports FY2023 net loss of $73.8M, advances PYX-201 and PYX-106 trials
Net loss of $73.8M ($1.85/share) vs $120.7M ($3.65/share) in FY2022; R&D expenses fell to $49.6M from $86.1M.
Pyxis Oncology appoints Santhosh Palani, Ph.D., CFA to board; grant of 69,760 options
Santhosh Palani appointed to Pyxis Oncology board effective March 12, 2024.
Pyxis Oncology raises ~$50M in private placement of shares and pre-funded warrants
Gross proceeds of ~$50M from 8.85M shares at $4.78 and pre-funded warrants for 1.61M shares at $4.779.
Pyxis Oncology appoints Ken Kobayashi as Chief Medical Officer effective Nov 27, 2023
Ken Kobayashi appointed CMO effective Nov 27, 2023; will lead clinical and regulatory operations.
Net loss of $23.0M ($0.56 per share) for Q3 2023, vs $27.7M ($0.85 per share) in Q3 2022.
Pyxis Oncology files Apexigen audited FY22 results; net loss $32M, cash $14.8M
Apexigen FY22 net loss of $32.1M, revenue $0; R&D expense $23.0M, G&A $9.7M.
Pyxis Oncology completes all-stock acquisition of Apexigen for ~$10.7M
Pyxis issued ~4.3M shares (exchange ratio 0.1725) so Apexigen holders own ~10% of combined co.
Exchange ratio: 0.1725 Pyxis shares per Apexigen share; combined ownership ~90% Pyxis, ~10% Apexigen.
Pyxis Oncology Q2 net loss $15.9M; cash $144.1M; Apexigen deal on track for August close
Net loss $15.9M ($0.41/share) vs $25.6M ($0.79) in Q2 2022; loss narrowed on lower R&D and G&A.
Board size increased to seven members, effective upon closing of merger with Apexigen.
Pyxis Oncology shareholders elect three directors and ratify auditor
Rachel Humphrey, M.D. elected as Class I director: 13,536,830 for, 3,476,861 withheld, 10,500,726 broker non-votes.
Pyxis Oncology acquires Apexigen in ~$16M all-stock deal; CMO resigns
Merger valued at ~$16M enterprise value; implied $0.64 per Apexigen share; exchange ratio 0.1725 PYXS shares per APGN share.
Pyxis Oncology announces acquisition of Apexigen; no deal terms disclosed
Pyxis Oncology and Apexigen held a joint investor call on May 24, 2023 to discuss the proposed business combination.
Pyxis Oncology Q1 net loss $19.2M; cash $150.8M; ODD for PYX-201 in pancreatic cancer
Net loss of $19.2M ($0.54 per share) vs $31.4M ($0.97) in Q1 2022; R&D expenses $11.9M, G&A $9.1M.
Pyxis Oncology reprices executive stock options to $2.21 per share
Board approved reducing exercise prices of outstanding pre-IPO options from $5.34-$8.71 to $2.21, the closing price on March 24, 2023.
Pyxis Oncology FY2022 net loss $120.7M; CFO promoted to CFO & COO
Net loss $120.7M ($3.65/share) vs $76.0M ($8.95) in 2021; R&D spend rose to $86.1M from $51.0M.
Pyxis Oncology doses first subject in Phase 1 trial of ADC PYX-201 for solid tumors
First subject dosed in open-label, dose-escalation Phase 1 trial PYX-201-101; preliminary data expected early 2024.
FDA clears Pyxis Oncology INDs for PYX-201 ADC and PYX-106 immunotherapy
FDA cleared IND for PYX-201, an ADC targeting tumor microenvironment for breast, head/neck, lung, thyroid cancers.
Pyxis Oncology Q3 net loss $27.7M, expands Pfizer ADC licensing deal
Net loss of $27.7M ($0.85 per share) for Q3 2022 vs. $14.2M ($8.96 per share) in Q3 2021.
Pyxis pays Pfizer $8M cash and issues ~2.23M shares ($5M) on closing, plus $5M in shares 180 days later.
Pyxis Oncology Q2 net loss $25.6M, cash $207M; stops PYX-202, prioritizes two lead programs
Cash $207M as of Aug 15, 2022; expected to fund operations through second half of 2024.
Pyxis Oncology appoints Jitendra Wadhane as Chief Accounting Officer
Mr. Wadhane appointed CAO and Principal Accounting Officer effective August 3, 2022.
Also on the Effective Date, Dr. Sullivan resigned from the Board of Directors of the Company.
On April 29, 2026 (the “Effective Date”), the Separation Agreement between the Company and Dr. Sullivan became binding and effective, addressing Dr. Sullivan’s separation from the Company.
Lara S. Sullivan, M.D., President and Chief Executive Officer will assume the role of Chief Medical Officer along with her current role as President and Chief Executive Officer.
On March 18, 2025, the Company announced that Ken Kobayashi, M.D., F.A.C.P, is stepping down from his position as the Company's Chief Medical Officer.
On June 10, 2024, Pyxis Oncology, Inc. (the “Company”), appointed Michael A. Metzger, to its Board of Directors (the “Board”).
On March 12, 2024, Pyxis Oncology, Inc. (the “Company”), appointed Santhosh Palani, Ph.D., CFA ® , to its Board of Directors (the “Board”).
On November 28, 2023, Pyxis Oncology, Inc. (the “Company”) announced the appointment of Ken Kobayashi, M.D., F.A.C.P, as Chief Medical Officer, effective as of November 27, 2023 (the “Effective Date”).
On August 23, 2023, effective as of the Effective Time, Jakob Dupont, M.D., a former director of Apexigen, was appointed to the Board as a Class III director and his term will expire at the annual meeting of stockholders to be held in 2024.
the Board also approved on a prospective basis the appointment of Jakob Dupont, M.D. as a director of the Company to fill the vacancy created by that action.
On May 24, 2023, the Company announced that Jay Feingold, M.D., Ph.D., will be stepping down from his position as the Company's Chief Medical Officer to pursue other opportunities.
On March 22, 2023, the Company announced that Pamela Connealy, Chief Financial Officer, has been promoted to the newly created role of Chief Financial Officer and Chief Operating Officer.
On August 11, 2022, Pyxis Oncology, Inc. appointed Rachel Humphrey, M.D., to its Board of Directors and to serve on the Board’s Nominating and Corporate Governance Committee and Compensation Committee.
Max materiality 0.85 · Median 0.60 · Most common event earnings