Gemma Brown
and Ms. Brown as principal accounting officer
Highest-materiality recent filing
Barinthus Bio Q1 net loss narrows to $5.5M; merger with Clywedog on track
Net loss of $5.5M ($0.14/shr) vs $19.6M ($0.49/shr) in Q1 2025.
Barinthus Bio reports FY2025 net loss $66.5M; merger with Clywedog on track for Q2 2026
Proposed all-stock merger with Clywedog expected to close Q2 2026; combined entity to trade as CLYD.
Barinthus Biotherapeutics receives Nasdaq delinquency notice over bid price below $1.00 per ADR
On Dec 30, 2025, Nasdaq notified Barinthus that its ADS bid price was below $1.00 for 30 consecutive business days, violating Listing Rule 5450(a)(1).
Barinthus Bio Phase 1 AVALON trial of VTP-1000 shows safety, dose-dependent effect in celiac disease
VTP-1000 well-tolerated in SAD portion; no treatment-related serious adverse events.
Barinthus Bio Q3 net loss $14.6M; all-stock merger with Clywedog
Net loss of $14.6M ($0.36/share) in Q3 2025 vs $21.1M loss in Q2 2025.
Barinthus (BRNS) merges with Clywedog; Clywedog stockholders to own ~66% of combined company
Clywedog stockholders will receive ~4.36 Topco shares per Clywedog share; Barinthus shareholders receive 1 Topco share per share.
Barinthus Bio amends 8-K to correct VTP-850 trial statement; reports Q2 net loss of $21.1M
Net loss $21.1M ($0.52/share) vs $19.7M ($0.49/share) in Q1 2025.
Barinthus Bio Q2 net loss $21.1M ($0.52/share); cash $87.8M, runway into 2027
Cash, cash equivalents & restricted cash $87.8M at June 30, 2025, down $12.8M from Q1.
Net loss $19.6M ($0.49/share) vs $15.5M ($0.40) in Q1 2024; R&D spending down to $8.3M from $11.1M.
Barinthus Bio FY2024 net loss $61.1M; cash runway into 2027; VTP-1000 data Q3 2025
Net loss of $61.1M ($1.55 per share) vs $73.3M in 2023; goodwill impairment of $12.2M.
Barinthus Bio restructures: cuts 65% workforce, shifts focus to celiac VTP-1000
Workforce reduction of ~65%; plans to close UK site, consolidate operations in Germantown, MD.
Barinthus/Arbutus HBV data: 23% HBsAg loss with nivolumab; 2 functional cures in Phase 2b
IM-PROVE II Group C: 23% (3/13) on imdusiran + VTP-300 + low-dose nivolumab achieved HBsAg loss by Week 48.
Net loss of $8.1M ($0.21/sh) vs $16.9M ($0.43/sh) in Q2; revenue of $15.0M from AstraZeneca Vaxzevria royalty share.
Barinthus Bio Q2 2024 net loss $16.9M; prioritizes HBV and celiac programs; CMO hired
Net loss of $16.9M ($0.43 per share) compared to $15.5M ($0.40) in Q1 2024.
Pipeline focused on VTP-300 for chronic hepatitis B and VTP-1000 for celiac disease; ongoing Phase 1 trial of VTP-850 in prostate cancer to be completed.
Barinthus Bio VTP-300 data: 76% eligible to stop NUC therapy; significant HBsAg reduction vs placebo
HBV003 (Phase 2b): 76% (16/21) eligible for NUC discontinuation; 19% achieved undetectable HBsAg.
Barinthus Bio Q1 net loss $15.5M; VTP-200 misses stat sig; VTP-1000 IND cleared; CMO appointed
Net loss was $15.5M ($0.40/share), compared to $18.2M ($0.48) in Q1 2023; revenue nil.
Barinthus Bio Q1 net loss $15.5M ($0.40/sh); cash $130M; VTP-1000 IND cleared for celiac trial
Net loss attributable to shareholders of $15.5M vs $18.2M in Q1 2023; revenue nil (vs $0.5M).
and Ms. Brown as principal accounting officer
appointed William Enright, the Company’s Chief Executive Officer, as principal financial officer
Effective as of April 30, 2025, the Company terminated the employment of Gemma Brown as Chief Financial Officer in connection with its restructuring plan that was announced in 2025.
the employment of Gemma Brown effective as of April 30, 2025
the Company will terminate the employment of Graham Griffiths effective as of June 30, 2025
On November 25, 2024, Nadège Pelletier, Ph.D., notified Barinthus Biotherapeutics plc (the "Company") that she will step down as Chief Scientific Officer of the Company effective February 2, 2025.
Effective September 1, 2024 (the “Effective Date”), Barinthus Biotherapeutics plc (the “Company”) has promoted Graham Griffiths, the Company’s Chief Business Officer, to Chief Operating Officer.
Max materiality 0.90 · Median 0.65 · Most common event earnings