Highest-materiality recent filing
Acrivon Q2 2026 net loss $18.0M; cash $90.0M funds into Q4 2027
Net loss $18.0M vs $21.0M in Q2 2025; R&D expense $13.8M vs $16.2M prior year.
Acrivon stockholders OK 3M share equity plan increase; elect Tomsicek, Baum
Share reserve increased by 3M shares to 8,606,723; annual 5% auto-increase through 2032 approved.
Acrivon Q1 net loss $19.0M; cash $97.7M; key ACR-368 interim readout in H2 2026
Net loss $19.0M vs $19.7M YoY; R&D $15.2M, G&A $4.7M.
Acrivon Therapeutics Q4/FY2025 net loss $19M/$77.9M; cash $118.6M; ACR-368 52% cORR in serous EC
Net loss Q4 $19.0M, FY $77.9M; cash and securities $118.6M expected to fund into Q2 2027.
Acrivon terminates Akoya/Quanterix diagnostic deal; opens internal CLIA lab
Mutually terminated OncoSignature Companion Diagnostic Agreement with Akoya (Quanterix) effective Feb 25, 2026.
Interim data from ACR-368 Phase 2b registrational-intent trial presented at ESGO Congress on February 27, 2026.
ACR-368 Phase 2b: 39% ORR overall; in serous EC ≤2 prior lines, cORR 52% (N=23) and 67% in BM+ (N=12). Arm 3 expanding to EU, enrollment complete Q4 2026.
Acrivon Therapeutics Provides Clinical Data Updates for ACR-368 and Initial ACR-2316 Data
On January 8, 2026, Acrivon hosted a webcast and conference call featuring ACR-368 clinical data and program updates.
Acrivon Therapeutics Q3 2025 net loss $18.2M, cash $134.4M to fund into Q2 2027
Net loss of $18.2M for Q3 2025, improved from $22.4M in Q3 2024.
Syngeneic mouse model: sustained complete tumor regression and immune memory after multiple implant rounds over ~1 year.
Acrivon Q2 net loss $21.0M, cash $147.6M; advances ACR-368 and ACR-2316 trials
Net loss of $21.0M for Q2 2025, up from $18.8M in Q2 2024; R&D spend $16.2M.
Acrivon stockholders elect three Class III directors and ratify PwC as auditor
Quorum of 29,659,010 shares (94.59%) present at 2025 annual meeting on June 13.
Acrivon's ACR-368 shows 35% cORR in endometrial cancer; cash $164.8M
Q1 2025 net loss $19.7M vs $16.5M YoY; R&D spend $15.4M on trial advancement.
Acrivon Therapeutics appoints Mansoor Raza Mirza as CMO effective April 9, 2025
Dr. Mirza is a gynecologic oncology KOL who led registrational trials for Zejula (PARP inhibitor) and frontline endometrial cancer therapy.
Acrivon reports Q4/FY24 net loss $22.8M/$80.6M; ACR-368 endometrial cancer cORR 35% in BM+ patients
Cash $184.6M as of Dec 31, 2024; runway extended into 2027.
Acrivon reports ACR-368 35% ORR in refractory endometrial cancer; deprioritizes ovarian/bladder
Preliminary cash, cash equivalents and ST investments ~$184.6M as of Dec 31, 2024; runway into 2027.
Acrivon appoints Adam Levy as CFO; Rasmus Holm-Jorgensen steps down effective April 1, 2025
Rasmus Holm-Jorgensen resigns as CFO effective April 1, 2025, for personal reasons to pursue Europe-based opportunity; no disagreement.
Acrivon reports Q3 net loss $22.4M; ACR-368 shows 62.5% ORR in endometrial cancer
Net loss Q3 2024: $22.4M vs $14.5M in Q3 2023; R&D expenses rose to $18.9M from $10.3M.
Acrivon doses first patient in Phase 1 trial of WEE1/PKMYT1 inhibitor ACR-2316
First patient dosed two quarters ahead of original timeline for ACR-2316 Phase 1 trial in solid tumors.
ACR-368 endometrial cancer Phase 2: 62.5% ORR in OncoSignature+ patients; ACR-2316 IND cleared
Confirmed ORR of 62.5% (95% CI 30.4-86.5) in prospectively-selected OncoSignature+ endometrial cancer patients who progressed on anti-PD-1.
Acrivon Q2 net loss $18.8M; $220.4M cash; ACR-368 Phase 2 shows 50% ORR
Net loss of $18.8M vs $13.9M YoY; R&D expenses $15.0M, G&A $6.4M.
Kristina Masson, Sharon Shacham, and Ivana Magovčević-Liebisch were elected as Class II directors with 24.6M, 23.3M, and 24.5M votes in favor, respectively.
Acrivon Q1 net loss $16.5M; ACR-368 Phase 2b 50% ORR; $130M PIPE
Net loss $16.5M vs $12.8M YoY; R&D $11.5M, G&A $6.2M.
Phase 2b: 50% confirmed ORR in OncoSignature-positive ovarian/endometrial (10 pts), 0% ORR in negative (16), p=0.0038.
Acrivon nets ~$130M in PIPE; shares at $8.50, pre-funded warrants for 7.1M shares
Gross proceeds ~$130M from 8.235M shares at $8.50/share and 7.06M pre-funded warrants at $8.499/warrant.
Acrivon reports Q4 2023 net loss of $19.3M; cash runway into Q4 2025
Net loss Q4 2023 $19.3M, full year $60.4M; R&D expenses $15.5M/$46.0M.
Acrivon appoints Santhosh Palani, Ph.D., CFA, to board of directors effective March 4, 2024
Dr. Palani appointed board member effective March 4, 2024; receives 32,500 share option grant vesting over 3 years.
Acrivon Therapeutics appoints Ivana Magovcevic-Liebisch, Ph.D., J.D., to board of directors
Appointment effective February 8, 2024; she will receive 32,500 stock options vesting over 3 years.
Acrivon updates corporate presentation at JPM; confirms cash runway into H2 2025
Participates in 42nd Annual J.P. Morgan Healthcare Conference on January 11, 2024.
Acrivon expands Akoya companion diagnostic deal to $17.3M for ACR-368 OncoSignature test
Third Amendment with Akoya increases total milestone payments to $17.3M through FDA pre-market approval for multiple indications.
Acrivon Q3 net loss $14.5M; cash $142.1M; ACR-368 shows early clinical activity
Net loss of $14.5M in Q3 2023 vs $9.2M in Q3 2022; R&D expenses $10.3M, G&A $5.9M.
Acrivon announces dual WEE1/PKMYT1 inhibitor ACR-2316; plans IND by Q4 2024
ACR-2316 is a novel dual WEE1/PKMYT1 inhibitor designed using Acrivon’s AP3 precision proteomics platform.
Acrivon posts Q2 2023 net loss of $13.9M; cash $151M funds ops into 2025
Net loss $13.9M vs $5.8M in Q2 2022; R&D expenses $10.5M, up from $4.1M.
Acrivon Therapeutics stockholders elect two Class I directors and ratify auditor
Michael Tomsicek elected Class I director with 17,527,002 votes for and 226,168 withheld.
Acrivon Therapeutics amends EVP Kristina Masson's employment agreement with $382,200 base salary
Amended employment agreement with Kristina M. Masson, EVP of Business Operations and board member, effective June 1, 2023.
Acrivon Q1 net loss $12.8M vs $7.2M YoY; cash $159.5M; FDA Fast Track for ACR-368
Net loss $12.8M for Q1 2023, widened from $7.2M in Q1 2022; R&D expense $9.8M (up from $6.1M).
Acrivon reports $159.5M cash as of March 31, 2023; runway into Q4 2024
Cash and marketable securities totaled $159.5M as of March 31, 2023 (preliminary, unaudited).
Acrivon provides pipeline and AP3 update, reports cash runway into Q4 2024
Hosted virtual investor event on May 1, 2023 with updated corporate presentation.
Acrivon updates pipeline and AP3 data; cash runway into Q4 2024
Cash and marketable securities as of Dec 31, 2022 provide runway into at least Q4 2024.
Acrivon Therapeutics reports FY 2022 net loss $31.2M, cash runway into Q4 2024
Net loss for FY 2022 was $31.2M vs $16.2M in 2021; Q4 net loss $8.9M vs $4.3M.
Cash and marketable securities $169.6M as of Dec 31, 2022 (preliminary, unaudited); projected runway into at least Q4 2024.
Acrivon Therapeutics sets 2023 annual meeting for June 22, 2023
First annual meeting of stockholders scheduled for June 22, 2023.
Acrivon Therapeutics completes IPO and concurrent $5M private placement with Chione Limited
Closed IPO and concurrent $5M private placement with Chione Limited on Nov 17, 2022.
On March 11, 2025, Rasmus Holm-Jorgensen, the Company’s Chief Financial Officer, notified the Company of his decision to step down from his position, effective April 1, 2025, for personal reasons to pursue another opportunity with a company based in Europe, allowing him to spend more time near his family.
On March 14, 2025, Acrivon Therapeutics, Inc. (the “Company”) appointed Adam Levy, Ph.D., M.B.A., to the position of Chief Financial Officer, effective as of April 1, 2025 (the “Effective Date”).
On March 1, 2024, the Board of Directors of Acrivon Therapeutics, Inc. (the “Company”) appointed Santhosh Palani, Ph.D., CFA, as a director of the Company, effective March 4, 2024.
On February 7, 2024, the Board of Directors of Acrivon Therapeutics, Inc. (the “Company”) appointed Ivana Magovcevic-Liebisch, Ph.D., J.D., as a director of the Company, effective February 8, 2024.
Max materiality 0.85 · Median 0.60 · Most common event other_material