Recent 8-K filings for CRNX

• September 1, 2026, 9:26 AM ET M&A materiality 1.00 neutral item 1.02item 2.01item 3.01item 3.03item 5.01item 5.02item 5.03item 9.01 ◈ executive_change ×12

  Crinetics completes $10B acquisition by Vertex at $85/share

  Merger completed Sept 1, 2026; Crinetics shareholders receive $85.00 per share cash.

• August 28, 2026, 5:00 PM ET M&A materiality 0.90 positive item 5.07item 9.01

  Crinetics shareholders approve Vertex merger; closing expected Sept 1, 2026

  Merger adoption approved: 79,240,098 for, 13,618 against, 10,915 abstain.

• August 19, 2026, 4:04 PM ET M&A materiality 0.80 negative item 8.01

  Crinetics supplements proxy disclosures amid shareholder lawsuits over Vertex merger

  Three shareholder lawsuits filed Aug 6 & 17, 2026 in NY and CA allege misleading proxy disclosures; seek to block merger.

• August 14, 2026, 8:30 AM ET M&A materiality 0.75 positive item 8.01

  Crinetics-Vertex merger clears HSR and key antitrust hurdles; close expected early Sept

  HSR waiting period expired Aug 12, 2026 at 12:45 p.m. ET.

• August 3, 2026, 4:09 PM ET M&A materiality 1.00 positive item 2.02item 9.01

  Vertex to acquire Crinetics for $85/share (~$10B equity value); Q2 PALSONIFY revenue $24M

  Vertex to acquire Crinetics for $85.00 per share cash, total equity value ~$10.0B (~$8.8B net of cash).

• July 10, 2026, 4:01 PM ET M&A materiality 0.75 neutral item 1.01item 5.02

  Crinetics enters into merger agreement with Vertex Pharmaceuticals

  Merger agreement signed July 6, 2026; Crinetics to become wholly owned subsidiary of Vertex.

• July 6, 2026, 5:17 PM ET M&A materiality 0.90 positive item 1.01item 8.01item 9.01

  Vertex to acquire Crinetics for $85/share, ~$10B equity value, adding PALSONIFY and atumelnant

  Vertex to acquire Crinetics for $85.00 per share in cash, total equity value ~$10.0B (~$8.8B net of cash).

• May 7, 2026, 7:59 PM ET earnings materiality 0.70 positive item 2.02item 9.01 ◈ Earnings Releases

  Crinetics Q1 2026: PALSONIFY net revenue $10.3M; EU approval; net loss $127.8M

  PALSONIFY net product revenue $10.3M in Q1 2026, up from $5.4M in Q4 2025; 232 enrollment forms received.

• March 23, 2026, 7:59 PM ET leadership materiality 0.60 negative item 5.02

  Crinetics' Chief Development and Operating Officer resigns effective April 10, 2026

  Jeff Knight resigns as Chief Development and Operating Officer, effective April 10, 2026.

• February 26, 2026, 6:59 PM ET earnings materiality 0.80 neutral item 2.02item 9.01

  Crinetics Q4 2025: Palsonify launch revenue $5.4M, net loss $122.8M; EU CHMP positive opinion

  PALSONIFY net product revenue $5.4M in Q4 2025; >200 enrollment forms by Dec end; 125+ HCPs prescribed in Q4.

• January 13, 2026, 6:59 PM ET earnings materiality 0.60 positive item 2.02item 7.01item 9.01

  Crinetics reiterates preliminary Q4 2025 PALSONIFY net product revenue over $5.0M

  Net product revenue from PALSONIFY (paltusotine) exceeds $5.0M for Q4 2025.

• January 7, 2026, 6:59 PM ET other material materiality 0.75 neutral item 8.01item 9.01

  Crinetics prices $350M common stock offering at $45.95/share to fund PALSONIFY launch

  Pricing: 7,620,000 shares at $45.95/share; gross proceeds ~$350M.

• January 5, 2026, 6:59 PM ET other material materiality 0.85 positive item 2.02item 7.01item 8.01item 9.01

  Crinetics PALSONIFY Q4 net revenue >$5M; atumelnant Phase 2 CAH shows 67% A4 reduction

  Unaudited Q4 2025 PALSONIFY net product revenue exceeded $5.0M, with >200 enrollment forms and >125 unique prescribers.

• December 17, 2025, 6:59 PM ET leadership materiality 0.60 neutral item 5.02item 9.01

  Crinetics CMO Dana Pizzuti steps down; transitions to advisor roles with $577k severance

  Dr. Dana Pizzuti steps down as CMO effective Dec 31, 2025; serves as Strategic Regulatory and Development Advisor through Mar 31, 2026.

• November 6, 2025, 6:59 PM ET earnings materiality 0.70 neutral item 2.02item 9.01

  Crinetics Q3 net loss $130.1M; PALSONIFY launched for acromegaly after FDA approval

  PALSONIFY (paltusotine) approved by FDA Sept 25 for first-line acromegaly; ~95% of top-priority HCP targets called, ~50% of filled prescriptions reimbursed.

• September 26, 2025, 7:59 PM ET regulatory materiality 0.90 positive item 7.01item 8.01item 9.01

  Crinetics gets FDA approval for PALSONIFY (paltusotine) as first oral acromegaly treatment

  FDA approved PALSONIFY (paltusotine) for adults with acromegaly with inadequate response to surgery or not surgical candidates.

• August 7, 2025, 7:59 PM ET earnings materiality 0.65 neutral item 2.02item 9.01

  Crinetics reports Q2 net loss $115.6M; PDUFA for paltusotine on Sept 25, 2025

  Revenue $1.0M (vs $0.4M in Q2 2024); net loss widened to $115.6M from $74.1M YoY.

• June 26, 2025, 7:59 PM ET other material materiality 0.60 neutral item 7.01item 8.01item 9.01

  Crinetics R&D Day updates preclinical pipeline: TSHR antagonist, SST3 agonist, NDC platform

  CRN12755 (TSHR antagonist) decreased thyroid hormone (T4) in rat model and hyaluronic acid/IL-6 in TED patient orbital fibroblasts.

• February 27, 2025, 6:59 PM ET earnings materiality 0.70 neutral item 2.02item 9.01

  Crinetics reports FY2024 net loss $298.4M; cash $1.4B; paltusotine PDUFA Sept 25, 2025

  Net loss Q4 2024: $80.6M vs $60.1M YoY; full year $298.4M vs $214.5M.

• February 24, 2025, 6:59 PM ET leadership materiality 0.60 neutral item 5.02item 7.01item 9.01 ◈ executive_change

  Crinetics appoints Tobin Schilke as CFO effective Feb 28, 2025

  Tobin Schilke appointed CFO effective February 28, 2025, succeeding Marc Wilson.

• January 14, 2025, 6:59 PM ET other material materiality 0.75 positive item 7.01item 9.01

  Crinetics outlines 2025 milestones: paltusotine PDUFA Sept 25, atumelnant Ph3 start H1 2025

  Paltusotine NDA under FDA review; PDUFA target action date set for September 25, 2025.

• January 10, 2025, 6:59 PM ET other material materiality 0.85 positive item 7.01item 8.01item 9.01

  Crinetics' atumelnant Phase 2 CAH trial meets primary endpoint with up to 80% mean A4 reduction

  Atumelnant reduced androstenedione up to 80% (120mg, p<0.0001); 80mg dose reduced by 774 ng/dL (p<0.0001).

• December 16, 2024, 6:59 PM ET leadership materiality 0.65 positive item 5.02item 7.01item 9.01

  Crinetics appoints Isabel Kalofonos as CCO ahead of paltusotine launch

  Isabel Kalofonos named Chief Commercial Officer, effective Dec 16, 2024; leads paltusotine (once-daily SST2 agonist for acromegaly) launch prep and pipeline commercialization.

• December 9, 2024, 6:59 PM ET regulatory materiality 0.85 positive item 8.01item 9.01

  Crinetics announces FDA acceptance of NDA for paltusotine in acromegaly; PDUFA Sept 25, 2025

  FDA accepted Crinetics' NDA for once-daily oral paltusotine for adult acromegaly patients.

• November 12, 2024, 6:59 PM ET earnings materiality 0.75 neutral item 2.02item 9.01

  Crinetics reports Q3 net loss $76.8M; submits NDA for paltusotine; raises $575M

  Net loss of $76.8M in Q3 2024 vs $57.5M in Q3 2023; revenue $0 vs $0.3M from SKK licensing.

• October 9, 2024, 7:59 PM ET other material materiality 0.75 neutral item 8.01item 9.01

  Crinetics prices upsized $500M public offering at $50/share; net proceeds ~$472M

  Pricing of 10,000,000 shares of common stock at $50.00/share for gross proceeds of $500.0 million.

• September 26, 2024, 7:59 PM ET regulatory materiality 0.75 positive item 8.01item 9.01

  Crinetics submits NDA to FDA for paltusotine for acromegaly; Phase 3 data support submission

  NDA supported by 18 clinical trials including two Phase 3 PATHFNDR studies; all primary and secondary endpoints met.

• September 17, 2024, 7:59 PM ET leadership materiality 0.60 neutral item 5.02 ◈ executive_change

  Crinetics CCO James Hassard to depart effective October 14, 2024

  James Hassard separates as Chief Commercial Officer; last day October 14, 2024.

• August 8, 2024, 7:59 PM ET earnings materiality 0.75 neutral item 2.02item 5.02item 9.01 ◈ executive_change

  Crinetics Q2 net loss $74.1M; CFO Wilson departs; paltusotine NDA on track for H2 2024

  Net loss of $74.1M in Q2 2024 vs $51.0M in Q2 2023; R&D expenses rose to $58.3M from $40.6M.

• June 21, 2024, 7:59 PM ET other material materiality 0.70 neutral item 8.01item 9.01

  Crinetics enters ATM equity offering agreement for up to $350M

  Filed prospectus supplement registering up to $350M in common stock sales.

• June 3, 2024, 7:59 PM ET other material materiality 0.75 positive item 7.01item 8.01item 9.01

  Crinetics posts positive Phase 2 data for atumelnant; paltusotine NDA on track for 2H 2024

  Atumelnant: 100% of CAH (n=6) achieved A4 below ULN; 100% of ADCS (n=5) normalized UFC at 80 mg once daily.

• May 9, 2024, 7:59 PM ET earnings materiality 0.65 neutral item 2.02item 9.01 ◈ Earnings Releases

  Crinetics Q1 net loss $66.9M; paltusotine NDA on track for 2H 2024

  Net loss of $66.9M in Q1 2024 vs $46.0M in Q1 2023; revenue fell to $0.6M from $2.7M.

• May 8, 2024, 7:59 PM ET other material materiality 0.70 positive item 7.01item 9.01

  Crinetics to present initial atumelnant Phase 2 data in CAH and Cushing's at ENDO 2024

  Five abstracts, four late-breaking, to be presented at ENDO 2024 (June 1-4, Boston).

• March 19, 2024, 7:59 PM ET other material materiality 0.85 positive item 7.01item 8.01item 9.01

  Crinetics paltusotine meets all endpoints in Phase 3 acromegaly study; NDA planned 2H 2024

  Primary endpoint: 56% of paltusotine patients achieved IGF-1 ≤1.0 xULN vs 5% placebo (p<0.0001).

• March 12, 2024, 7:59 PM ET other material materiality 0.75 positive item 7.01item 8.01item 9.01

  Crinetics reports positive Phase 2 results for paltusotine in carcinoid syndrome

  Phase 2 trial: 63% reduction in mean flushing frequency (p<0.0001) for patients with >1/day at baseline.

• March 1, 2024, 6:59 PM ET other material materiality 0.75 positive item 1.01item 3.02item 8.01item 9.01 ◈ Material Agreements

  Crinetics raises $350M in oversubscribed private placement of 8.33M shares at $42/sh

  Private placement of 8,333,334 common shares at $42.00/share raises ~$350M gross proceeds.

• February 28, 2024, 6:59 PM ET earnings materiality 0.75 negative item 2.02item 9.01 ◈ Earnings Releases

  Crinetics reports Q4 net loss of $60.1M; announces $350M private placement; paltusotine NDA on track for 2H 2024

  Net loss for Q4 2023 was $60.1M vs $45.0M in Q4 2022; full-year net loss $214.5M vs $163.9M in 2022.

• January 8, 2024, 6:59 PM ET other material materiality 0.65 neutral item 7.01item 9.01

  Crinetics outlines 2024 milestones: paltusotine Phase 3 data Q1, CRN04894 data Q2

  Phase 3 PATHFNDR-2 trial of paltusotine in acromegaly on track for topline data in Q1 2024.

Executive changes

Earnings & guidance

Materiality & sentiment trend

Max materiality 1.00 · Median 0.70 · Most common event other_material

18 positive 3 negative 29 neutral

source · CRNX on sec.gov