Highest-materiality recent filing
Shareholders approved 3M share increase under 2022 Equity Incentive Plan and 1.4M under ESPP at May 21 annual meeting.
Karyopharm Q1 revenue $35.1M, net loss $22.4M; Phase 3 endometrial trial enrollment complete
U.S. XPOVIO net product revenue $29.2M (up from $21.1M YoY) on lower gross-to-net adjustments.
Karyopharm raises ~$50M via private placement and ATM; cash runway into late Q3 2026
Private placement with RA Capital Management closed March 26: 1.03M shares at $6.785, pre-funded warrants for 3.39M shares, and warrants for 4.42M shares at $10.00 exercise.
Karyopharm SENTRY trial meets spleen endpoint, misses symptom; DLBCL withdrawal agreed
SENTRY trial: 50% SVR35 at wk24 vs 28% for ruxolitinib alone (p<0.0001); Abs-TSS comparable, not significant.
Karyopharm defers debt payments, requires $25M equity raise to extend runway past mid-2026
Second Amendment to Credit Agreement defers June 2026 principal payment to September 10, 2026; interest due June 30 paid in kind.
Karyopharm shareholders approve increase in authorized shares to 111M at special meeting
Authorized common stock raised from 53,333,333 to 106,000,000; total capital shares from 58,333,333 to 111,000,000.
FY2025 total revenue $146.1M (up from $145.2M); U.S. XPOVIO net product revenue $114.9M (up from $112.8M).
Preliminary total revenue for 2025 ~$145M; Q4 2025 ~$33M. U.S. XPOVIO net product revenue 2025 ~$115M; Q4 ~$32M.
Karyopharm Q3 net loss $33.1M; XPOVIO revenue up 8.5%; SENTRY data March 2026
Total rev $44.0M ($38.8M Q3 2024); U.S. XPOVIO net product rev $32.0M (+8.5% vs $29.5M).
Karyopharm closes $131M debt financing; issues 9% convertible notes, waives defaults
Borrowed $12.5M under amended credit agreement; issued $15M 2028 and $103.5M 2029 convertible notes at 9%.
KPTI closes $67.5M debt package, note exchanges & $8.75M equity; runway into Q2 2026
$27.5M new term loan (SOFR+10.25%), $25M interest/royalty deferrals, $15M liquidity covenant relief.
Karyopharm Therapeutics director Mansoor Raza Mirza resigns from board effective Sept 8, 2025
Mansoor Raza Mirza, M.D. resigned from the Board of Directors due to competing professional demands.
Karyopharm Q2 net loss $37.3M; explores financing/strategic alternatives; cash $52M
Total revenue $37.9M; US XPOVIO net product revenue $29.7M (+6% YoY). Net loss $37.3M ($4.32/share).
Karyopharm cuts workforce 20%, explores strategic alternatives including sale
Reducing workforce by ~20% as part of ongoing expense management; one-time costs immaterial.
Karyopharm shareholders approve 450,000 share increase to equity plan at annual meeting
Elected Garen G. Bohlin and Zhen Su as Class III directors with 3,066,819 and 3,191,845 votes for, respectively.
Total revenue $30.0M; U.S. XPOVIO net product revenue $21.1M, impacted by $5.0M increase in product return reserve for expired 80 mg and 100 mg units.
Karyopharm files 1-for-15 reverse stock split effective Feb 25 to meet Nasdaq bid price rule
Reverse stock split 1-for-15 effective Feb 25, 2025 at 5pm ET; post-split trading starts Feb 26.
Karyopharm Q4/FY2024 rev $145M; guides FY2025 rev $140-155M; trial updates
FY2024 total revenue $145.2M (flat YoY); net product revenue $112.8M (vs $112M). Q4 net product rev $29.3M (+17% YoY).
Named executives Sohanya Chang, Stuart Poulton, and Reshma Rangwala each receive 137,500 options and 68,750 RSUs, effective Feb 28, 2025.
Karyopharm shareholders approve reverse stock split and share increase
Approved increase in authorized capital stock to 805M shares (common to 800M).
Karyopharm estimates FY2024 total rev ~$145M; Phase 3 MF data in 2H 2025
Preliminary FY2024 total revenue ~$145M, XPOVIO net product rev ~$113M; Q4 rev ~$30M, XPOVIO ~$29M.
Karyopharm appoints Lori Macomber as CFO effective Jan 3, 2025
Macomber previously CFO at Legend Biotech, will serve as EVP, CFO and Treasurer.
Karyopharm pauses endometrial cancer program update; in talks with FDA about Phase 3 trial
Company in discussions with FDA regarding evolving treatment landscape for endometrial cancer and its impact on Phase 3 XPORT-EC-042 trial.
Karyopharm appoints Kristin Abate as VP, Chief Accounting Officer, effective Nov 20, 2024
Kristin Abate appointed Vice President, Chief Accounting Officer, and Assistant Treasurer, effective November 20, 2024.
Karyopharm reduces office space by 46,278 sq ft, extends lease for remaining space through 2030
Reduces leased premises by 46,278 rentable square feet (from 98,502 to 52,224) effective Sept 30, 2025.
Karyopharm Q3 total revenue $38.8M, net loss $32.1M; narrows FY2024 guidance
U.S. XPOVIO net product revenue $29.5M in Q3, down from $30.2M in Q3 2023; total revenue up to $38.8M from $36.0M.
Co-primary endpoint changed from TSS50 to Abs-TSS following FDA alignment; SVR35 remains co-primary.
Karyopharm receives Nasdaq deficiency notice for bid price below $1.00
Stock closed below $1.00 for 32 consecutive business days, violating Bid Price Rule 5450(a)(1).
Karyopharm CFO Michael Mason to resign Nov 5; transition agreement signed
Michael Mason, EVP/CFO/Treasurer, notified resignation effective November 5, 2024; will serve until then.
Karyopharm Q2 revenue $42.8M, net income $23.8M on debt gain; raises FY guidance low end
Q2 2024 total revenue $42.8M (Q2 2023: $37.6M); US XPOVIO net product revenue $28.0M (Q2 2023: $28.5M).
Karyopharm shareholders approve 6M share increase in equity plan, 5M in ESPP, and option exchange
Stockholders approved Class II directors: Deepika R. Pakianathan, Richard Paulson, Chen Schor (all three-year terms).
Exchanged ~$148M of 3.00% convertible notes due 2025 for $111M of new 6.00% secured convertible notes due 2029.
Karyopharm Q1 total revenue $33.1M, net loss $0.32/share; extends debt maturities to 2028/2029
Q1 2024 total revenue $33.1M (vs $38.7M Q1 2023); U.S. XPOVIO net product revenue $26.0M (vs $28.3M Q1 2023).
Karyopharm closes $100M term loan, exchanges $148M old notes for $111M new 6% notes + warrants
$100M senior secured term loan at SOFR+9.25%, matures May 2028; liquidity covenant $25M minimum.
On November 20, 2024, Karyopharm Therapeutics Inc. (the “Company”) announced the appointment of Kristin Abate, the Company’s Vice President, Accounting, Corporate Controller and Assistant Treasurer, as the Company’s Vice President, Chief Accounting Officer, and Assistant Treasurer, effective November 20, 2024.
On August 26, 2024, Michael Mason notified Karyopharm Therapeutics Inc. (the “Company”) of his intention to resign as the Company’s Executive Vice President, Chief Financial Officer and Treasurer to pursue other professional interests.
Max materiality 0.95 · Median 0.70 · Most common event earnings